Hydroxyapatite (HA) is a naturally occurring mineral form of calcium apatite, primarily found in bone and teeth. Its chemical formula is Ca10(PO4)6(OH)2, which indicates that it is composed of calcium phosphate with hydroxyl ions. Hydroxyapatite plays a crucial role in providing structural integrity and strength to bones and teeth.
Hydroxyapatite Series Products List
| Catalog Number | Product Name | Average Particle Size | Purity | Inquiry |
| ACM1306065-7 | Hydroxyapatite Powder | 200 nm | ≥ 95% | Inquiry |
| ACM1306065-23 | Hydroxyapatite Powder | 60 nm | 99.90% | Inquiry |
| ACM1306065-9 | Hydroxyapatite, Spherical-like | 2um | 96% | Inquiry |
| ACM1306065-10 | Hydroxyapatite, Spherical-like | 200nm | 95% | Inquiry |
| ACM1306065-11 | Hydroxyapatite, Needle-shaped | 60nm | 96% | Inquiry |
| ACM1306065-12 | Hydroxyapatite, Needle-shaped | 40nm | 96% | Inquiry |
| ACM1306065-13 | Hydroxyapatite, Needle-shaped | 20nm | 97.50% | Inquiry |
| ACM1306065-14 | Hydroxyapatite, Needle-shaped | 20nm | 99% | Inquiry |
| ACM1306065-15 | Hydroxyapatite, Clavate/Fibroid | 20nm | 99% | Inquiry |
| ACM1306065-16 | Hydroxyapatite, Spherical | 80um | 96% | Inquiry |
| ACM1306065-17 | Hydroxyapatite, Spherical | 15um(≤30um) | | Inquiry |
| ACM1306065-18 | Hydroxyapatite, Spherical | 50um(30-80um) | | Inquiry |
| ACM1306065-19 | Hydroxyapatite, Spherical | 100um(≥80um) | | Inquiry |
| ACM1306065-20 | Hydroxyapatite, Spherical | 200um | | Inquiry |
| ACM1306065-21 | Hydroxyapatite, Spherical | 25-45um | | Inquiry |
| ACM1306065-22 | Hydroxyapatite, Spherical | 1-3mm | | Inquiry |
| ACM1306065-24 | Hydroxyapatite Powder | 120um | | Inquiry |
| ACM1306065-25 | Hydroxyapatite Powder | ≤29um | | Inquiry |
Here are several key functions and effects of hydroxyapatite in the body:
Hydroxyapatite for Bone Structure and Strength
Hydroxyapatite is the primary inorganic component of bone tissue, contributing to its rigidity and strength. It provides the mineral phase that gives bones their structural integrity. One of the primary functions of hydroxyapatite in bone is to maintain its architecture and mechanical properties. Bone is a composite material, made up of an organic matrix (primarily collagen) and inorganic minerals, with hydroxyapatite making up about 70% of its mass. This combination allows bone to have both tensile strength and toughness, enabling it to withstand various mechanical loads and stresses.
The hexagonal crystals of hydroxyapatite are arranged in a specific pattern within the collagen matrix, giving bones their characteristic rigidity and strength. The crystalline structure facilitates mineralization, a process where minerals deposit in the organic matrix to strengthen bones. This structured mineralization leads to the formation of a robust, resilient bone tissue capable of supporting the body and withstanding forces from movement and weight.
Hydroxyapatite is also integral to the process of bone remodeling, which involves the continuous renewal of bone tissues through the actions of osteoblasts (bone-forming cells) and osteoclasts (bone-resorbing cells). Proper regulation of hydroxyapatite is vital for maintaining bone density and strength throughout life. In the context of osteoporosis and other bone-related diseases, an imbalance in the formation and resorption of hydroxyapatite can lead to weakened bones and fractures.
Hydroxyapatite for Tooth Structure
In dental health, hydroxyapatite is a major component of tooth enamel and dentin. It helps maintain the hardness and resilience of teeth, protecting them from decay.
Teeth are primarily composed of enamel, dentin, and cementum—each of which contains hydroxyapatite. Enamel, the outermost layer, is the hardest substance in the human body and is made up of about 95% mineral content, predominantly hydroxyapatite. Dentin, the layer beneath the enamel, consists of approximately 70% mineral content, again primarily in the form of hydroxyapatite. The presence of hydroxyapatite in these layers provides strength and resilience to the teeth, helping them withstand the forces of mastication (chewing).
The formation of hydroxyapatite crystals is an essential part of the biomineralization process, which is critical for tooth development. During this process, specialized cells called ameloblasts synthesize enamel proteins, which later mineralize to form hydroxyapatite crystals. Similarly, odontoblasts contribute to dentin formation by secreting dentin matrix proteins that mineralize into hydroxyapatite. This dynamic process is vital for the proper development and maturity of tooth structure.
Hydroxyapatite also plays a pivotal role in the remineralization of teeth. Acidic conditions in the mouth, often due to plaque or dietary sugars, can lead to demineralization of enamel, resulting in cavities. Hydroxyapatite can be reintroduced into the oral environment through dental treatments and oral care products, such as toothpaste containing nano-hydroxyapatite. This application helps restore the mineral content of enamel, promoting repair and reducing the risk of caries (tooth decay).
Hydroxyapatite for Calcium Regulation
Hydroxyapatite acts as a reservoir for calcium and phosphate, minerals essential for various biological processes, including cellular functions and metabolic activities. It helps regulate the levels of these minerals in the body. It serves as a major reservoir for calcium and phosphate ions, which are vital for various physiological processes.
Hydroxyapatite is a key player in the process of bone mineralization. During bone formation, osteoblasts (bone-forming cells) secrete collagen and non-collagenous proteins, which provide a scaffold for the deposition of hydroxyapatite crystals. This mineralization process is crucial for maintaining bone density and strength, and it helps regulate the levels of calcium and phosphate in circulation.
The body maintains calcium homeostasis through a complicated interplay between dietary intake, renal excretion, and mobilization from bone. Hydroxyapatite serves as a reservoir that can release or absorb calcium ions as needed to maintain stable levels of calcium in the bloodstream. When serum calcium levels drop, osteoclasts can resorb bone, breaking down hydroxyapatite and releasing calcium back into circulation. Conversely, when calcium levels are high, the formation of hydroxyapatite in the bone structure can help mitigate hypercalcemia by sequestering excess calcium.
Potential Therapeutic Uses of Hydroxyapatite
Hydroxyapatite is being explored for various therapeutic applications, including drug delivery systems, scaffolding for tissue engineering, and treatments for conditions like osteoporosis or dental caries.
Hydroxyapatite, a naturally occurring mineral form of calcium apatite, has garnered significant attention in the field of medicine due to its potential therapeutic applications. This bioceramic material closely resembles the mineral component of bone, which makes it particularly suitable for various medical and dental applications.
Hydroxyapatite has shown promise as a carrier for drug delivery, particularly in the targeted release of therapeutic agents. Its porous structure can be engineered to encapsulate various drugs, allowing for controlled release over time. This property is particularly useful in treating bone-related illnesses, as it can deliver medications directly to affected areas, minimizing systemic side effects.
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Hydroxyapatite Series Products
